Max Melnikas
M.R. Bauer Foundation Summer Science Research Fellow
Xu Lab, Department of Chemistry
Brandeis University
Efficient Synthesis of Tri-O-Acetyl-D-Galactal from a Readily-Available D-(+)-Galactose Starting Material
The purpose of this summer research project was to learn general laboratory techniques and grow comfortable with a chemical research environment. To achieve this goal, I focused on learning and perfecting a 3-step pathway that converts readily available D-(+)-Galactose into biologically active Tri-O-acetyl-D-Galactal. This galactal derivative, once selectively protected, can be used as a building block to synthesize oligosaccharides in a highly controlled manner. Ultimately, these pathways could lead to more efficient synthesis of crucial biological molecules and medications like Heparin and Tn Antigen. Throughout this project, I learned the series of steps that are used to convert a common starting material into a pure, desired product. Some of the techniques involved in these steps include extraction, evaporation under reduced pressure and purification through flash chromatography. Most of all, participating in summer research has allowed me to develop as a problem solver, critical thinker, and above all, a scientist.
Personal Statement and Pandemic Reflection
The opportunity to conduct in-person research and participate in a laboratory setting has been a very welcome change from a year full of online learning. Going into this experience, I was facing challenges caused by my fully online organic chemistry laboratory experience. This class teaches the foundational techniques that form all organic chemistry research. The inability to attend in-person sessions left gaps in my practical knowledge that I had to address before commencing any meaningful research.
Luckily for me, the principal investigator of my group cared deeply about my learning and the graduate students were incredibly helpful and patient. Nearing the end of the summer, I feel like I have grown confident in the standard practices of an organic chemistry laboratory. Additionally, by working side by side with the graduate students and other undergraduates, I have developed as a learner, a teacher, and a teammate.